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KMID : 0616120160470010001
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 1 p.1 ~ p.6
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Phenolic Compounds from the Twigs of Corylopsis coreana Uyeki and Their Cytotoxic Activity
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Kwon Oh-Kil
Kim Chung-Sub
Suh Won-Se
Park Kyoung-Jin
Cha Joon-Min
Choi Sang-Un
Kwon Hak-Cheol
Lee Kang-Ro
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Abstract
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Phytochemical investigation of the twigs of Corylopsis coreana afforded 10 phenolic compounds, bergenin (1), 6′-O-galloylbergenin (2), 3′-O-galloylbergenin (3), (-)-catechin (4), (-)-epicatechin (5), (-)-epicatechin-3-O-galloyl ester (6), 4-methoxy-3,-5-dihydroxybenzoic acid (7), gallic acid (8), 2,4,6-trimethoxyphenol-1-O-b-D-glucopyranoside (9), and 2,4,6-trimethoxyphenol-1-O-b-D-(6-O-galloyl)-glucopyranoside (10). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. The compounds 3, 9 and 10 were isolated for the first time from this source. All the isolates (1-10) were tested for their cytotoxic activity against A549, SK-OV-3, SK-MEL-2, and HCT15 cell lines in vitro using the SRB bioassay. The compounds 5, 7 and 8 exhibited selective cytotoxic activity against SK-MEL-2 cell line.
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KEYWORD
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Corylopsis coreana , Hamamelidaceae , Bergenin , Flavonoid , Cytotoxicity
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